Jose Mourinho men will take a short trip to Vicarage Road to take on Watford in the Premier League this night.
United limped to a 1-0 win over newly promoted Brighton on Saturday and will now face in-form Marco Silva men as they hope to bridge the gap between them and Manchester City.
The Hornets have won their last two successive games and has also taken points off Liverpool and Arsenal this season.
The Red Devils are currently eight points behind league leaders Manchester City and will need to get the three maximum against Watford if they are to remain in the title race.
Romeru Lukaku goal drought continues but will however be expected to have the nod over Zlatan Ibrahimovic in the attack.
Mourinho claimed he made a mistake fielding in too many attackers in his post-match briefing against Brighton over the weekend. As a result, we expect some changes in his starting eleven.
Nemanja Matic and Paul Pogba are both sure starter but Marouane Fellaini could be brought in to replace Juan Mata in the midfield.
A defensive partnership of Chris Smalling and Victor Lindelof is expected at the back while David de Gea continues in the goal post.
Goalkeeper: De Gea
Defenders: Valencia, Smalling, Lindelof and Young
Midfielders: Matic, Pogba and Fellaini
Attackers: Rashford,Matial and Lukaku.