Speaking in his press conference on Friday, Louis van Gaal revealed that three of his players will miss out as United host Sunderland on Saturday.
Marcos Rojo and Paddy McNair both miss out, as well as Luke Shaw who has begun his rehabilitation process on his broken leg.
The Argentine defender got his first start of the season at St. Mary’s last weekend, but a minor knock that he picked up ruled him out of the Ipswich tie midweek.
United’s young Paddy McNair replaced him, but he too took a knock that will keep him out of contention.
“We have to wait to see how the players recover because there are only two days between the two matches. Until now I don’t know how I’ll put the line-up.”
The United boss also gave an update on Luke Shaw’s progress, after the left-back suffered a double fracture to his right leg in United’s 2-1 defeat to PSV Eindhoven.
“I spoke to him last night, he was very positive – it’s amazing for me.
“There are very good signals, and we have already started the rehabilitation.
“He shall be visited at home for the first electro muscle stimulants, so I think [his progress] is very good.”
Shaw will be out for most of the season, but with an estimated recovery time of six to eight months, he could still feature before the campaign is over.